PRINCIPLES OF DRUG ADMINISTRATION
“Five Plus Five Rights”
of Drug Administration
of Drug Administration
?Right client
?Right drug
?Right dose
?Right time
?Right route
?Right documentation
?Right assessment
?Right to education
?Right evaluation
?Right to refuse
Factors Modifying the
Drug Response
Drug Response
?Absorption
?Distribution
?Metabolism (biotransformation)
?Excretion
?Age
?Body weight
?Toxicity
?Pharmacogenetics
?Route of administration
?Time of administration
?Emotional factors
?Preexisting disease state
?Drug history
?Tolerance
?Cumulative effect
?
Drug-food interaction
?
Drug-drug interaction
Forms and Routes
?Tablets and capsules
?Liquids
?Transdermal
?Topical